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Electrospun nanofibers for Sustained Delivery of Cetylpyridinium Chloride for Buccal Topical Application


Maria Helena Ambrosio Zanin; V.A. Santos; Adriano Marim de Oliveira ; Natlia Neto Pereira Cerize ; M.A. Borsatti.


Resumo:

Electrospun polymeric nanofibers were developed using polyvinylpyrrolidone (PVP-Kollidon® 90F), ammonio methacrylate copolymer type B (PMMA-Eudragit® RS100) and cetylpyridinium chloride (CPC), 10:10:1 (wt/wt%) for buccal topical application. The morphology of mats with and without the CPC was analyzed and also the the thermal behaviors and the physicochemistry characteristics of the nanofiber mats. The SEM images revealed that all of the fibers were smooth and the average diameter of fibers was from 200 nm to 500 nm. The thermal analysis showed that the incorporation of cetylpyridinium chloride in the nanofiber through electrospinning process changed the cristallinity of cetylpyridinium chloride and/or conferred to this drug a new amorphous state. The in vitro release of CPC from the fiber in PBS buffer (pH 7.4) showed a sustained release over the experimental time of 24 h and the drug did not permeated all the skin achieving the medium receptor.


Referência:
ZANIN, Maria Helena Ambrosio; SANTOS, V.A. ; OLIVEIRA, Adriano Marim de ; CERIZE, Natália Neto Pereira ; BORSATTI, M.A . Electrospun nanofibers for sustained delivery of cetylpyridinium chloride for buccal topical application. In: NANOTECH CONFERENCE AND EXPO, 18., 2015, Washington. Proceedings.... 4 p.